منابع مشابه
Role of isoenzyme M2 of pyruvate kinase in urothelial tumorigenesis
The conversion of precancerous lesions to full-fledged cancers requires the affected cells to surpass certain rate-limiting steps. We recently showed that activation of HRAS proto-oncogene in urothelial cells of transgenic mice causes simple urothelial hyperplasia (SUH) which is persistent and whose transition to low-grade papillary urothelial carcinoma (UC) must undergo nodular urothelial hype...
متن کاملPyruvate Kinase type M2 (PKM2) Promotes Cancer Cell Metastasis Through Interacting with TWIST-1
Tumor growth and metastasis are key processes in understanding tumor progression and cancer fatality. Pyruvate Kinase type M2 (PKM2) is a key enzyme that regulates glucose metabolism in cells in a biochemical pathway known as glycolysis. Glycolysis provides cells with energy (ATP) and building blocks (nucleic acids, amino acids and lipids) that are critical for cell survival and proliferation. ...
متن کاملThe transglutaminase type 2 and pyruvate kinase isoenzyme M2 interplay in autophagy regulation
Autophagy is a self-degradative physiological process by which the cell removes worn-out or damaged components. Constant at basal level it may become highly active in response to cellular stress. The type 2 transglutaminase (TG2), which accumulates under stressful cell conditions, plays an important role in the regulation of autophagy and cells lacking this enzyme display impaired autophagy/mit...
متن کاملFaecal pyruvate kinase isoenzyme type M2 for colorectal cancer screening: a meta-analysis.
AIM To present a critical discussion of the efficacy of the faecal pyruvate kinase isoenzyme type M2 (faecal M2-PK) test for colorectal cancer (CRC) screening based on the currently available studies. METHODS A literature search in PubMed and Embase was conducted using the following search terms: fecal Tumor M2-PK, faecal Tumour M2-PK, fecal M2-PK, faecal M2-PK, fecal pyruvate kinase, faecal ...
متن کاملPyruvate kinase M2 (PKM2) expression correlates with prognosis in solid cancers: a meta-analysis
Pyruvate kinase M2 (PKM2) is the key enzyme in the Warburg effect and plays a central role in cancer cell metabolic reprogramming. Recently, quite a few studies have investigated the correlation between PKM2 expression and prognosis in multiple cancer patients, but results were inconsistent. We therefore performed a meta-analysis to explore the prognostic value of PKM2 expression in patients wi...
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ژورنال
عنوان ژورنال: Atlas of Genetics and Cytogenetics in Oncology and Haematology
سال: 2011
ISSN: 1768-3262
DOI: 10.4267/2042/44450